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Chelsea matches where Nuno Santo was opposition manager/coach
| Date | Venue | Opponent | Score | Comp |
| 05/12/2018 | Molineux | Wolverhampton Wanderers | 1-2 | Premier League |
| 10/03/2019 | Stamford Bridge | Wolverhampton Wanderers | 1-1 | Premier League |
| 14/09/2019 | Molineux | Wolverhampton Wanderers | 5-2 | Premier League |
| 26/07/2020 | Stamford Bridge | Wolverhampton Wanderers | 2-0 | Premier League |
| 15/12/2020 | Molineux | Wolverhampton Wanderers | 1-2 | Premier League |
| 27/01/2021 | Stamford Bridge | Wolverhampton Wanderers | 0-0 | Premier League |
| 19/09/2021 | Tottenham Hotspur Stadium | Tottenham Hotspur | 3-0 | Premier League |